Cassadine family

The Cassadines are a fictional aristocratic family featured in the American soap opera General Hospital. Various members of the family have been residents of Port Charles and have owned several private island compounds worldwide, including Cassadine Island in Greece.

Background[]

Cassadine Victor-Alexis-Ava-Nikolas-Spencer 2022 — Victory toast at the MC Pool (2022)

The Cassadine family, descendants of Russian aristocracy and connected to the royal Romanovs, thrived in Russia for centuries. The 1917 Bolshevik Revolution compelled their flight to Greece, where they subsequently established a vast empire of wealth and power.

Fratelli cassadine — Cassadine brothers, Victor, Mikkos, and Tony (1981)

The Cassadines debuted in 1981 with Mikkos Ivanovich Cassadine, the family patriarch, and his brothers Victor and Tony, engaging in various sinister schemes, including the Ice Princess plot to freeze the world using a weather machine. Their plans were thwarted by Robert Scorpio, Luke Spencer, and Laura Webber, resulting in Mikkos and Tony's deaths during a confrontation, while Victor was apprehended. Subsequently, Mikkos' widow Helena Cassadine arrived in Port Charles to curse Luke and Laura at their wedding, seeking vengeance.

In 1982, the Cassadines kidnapped Laura and coerced her into marrying Helena's son, Stavros Nikolai Mikkosovich Cassadine, having deceived Laura into believing that Luke was dead. While held captive in Greece, Laura bore Stavros' son, Prince Nikolas Mikail Stavrosovich Cassadine. Upon learning that Luke was alive, Laura fled after a year of captivity, leaving Nikolas in Greece to be raised by his uncle, Stefan Darius Mikkosovich Cassadine, Helena's second son. Previously, Stefan and Laura had been romantically involved, and Laura had thought Stefan was Nikolas' father, not Stavros. Stavros pursued Laura back to Port Charles, seeking to reclaim his wife. However, following a confrontation with Luke, Stavros met his demise, seemingly dying after tumbling down a flight of stairs at General Hospital.

Dagger — Alexis holding the dagger Helena used to kill Alexis' mother (2016)

Stefan ultimately assumed leadership of the family, and in 1996, he and Nikolas relocated to Port Charles with Alexis Davis. It was later disclosed that Alexis was one of Mikkos' two illegitimate daughters with the Swedish opera singer Kristin Bergman, the other being Kristina Cassadine. Born Natasha Cassadine, Alexis, upon receiving her royal titles, renounced them and legally altered her surname to Davis. Helena, too, returned to Port Charles, fixated on seizing control of Nikolas, the heir to the Cassadine fortune.

In 2001, Helena resurrected her deceased son, Stavros, after a decade in the sub-basement laboratory of GH. His return was brief, as he was believed to have died permanently after Luke pushed him into a bottomless pit. That year, Alexis was elated to find her sister Kristina alive, hidden away by Mikkos from Helena. Alexis and Kristina developed a close relationship, but it was tragically ended a year later when Kristina died in a mob-related incident, devastating Alexis.

Cassadine FamilyDinner Rules — Helena, Stefan, Alexis, and Nikolas - family rules

In 2003, Luke and Stefan had their final confrontation, ending with Stefan being fatally stabbed at Wyndemere Castle on Spoon Island. With the apparent elimination of all vengeful Cassadines, Nikolas announced the end of the feud between the Spencers and the Cassadines. Years later, Nikolas faced single fatherhood when his fiancée, Courtney Matthews, passed away shortly after delivering their son, whom he named Spencer Cassadine.

Cassadine HelenaNikolas ActTrueCassadine 2015 — Embracing the legacy (2015)

In 2013, Helena was fatally shot aboard the Haunted Star by Luke. The shock continued as Luke and Laura discovered Stavros alive, holding Lulu Spencer captive on Cassadine Island. They rescued Lulu and exacted revenge by freezing Stavros in his ice chamber. Within a year, Victor Cassadine returned to Port Charles, having preserved Helena and Stavros' bodies, and revived them. Stavros was quickly killed again, and Victor was also shot dead. Helena survived a little over a year before her health declined, leading to her death on Cassadine Island. Posthumously, her journal disclosed that Nikolas had poisoned her, causing her death.

Cassadines Best Part of Me 2024 — Nikolas admits his sons are the best part of him (2024)

In 2016, Valentin Mikkosovich Cassadine was found on Cassadine Island, initially thought to be Mikkos' illegitimate son. Before her death, Helena disclosed that Mikkos had disowned Valentin at birth, stripping him of Cassadine privileges. Valentin took Nikolas' family and friends hostage, coercing Nikolas to relinquish his fortune. During a confrontation, Nikolas fell from a balcony, leading to his presumed death. Valentin fled to Port Charles, attempting to abduct and murder his grandnephew Spencer but was apprehended by the authorities. Concerned for Spencer's safety, Laura sent him to boarding school. Post Nikolas' supposed demise, Valentin was freed from prison and settled in Wyndemere. Valentin and Lulu Spencer have a daughter, Charlotte Honor Cassadine, born via IVF, over whom they have joint custody. It was later uncovered that Charlotte was intentionally conceived as Valentin and Lulu's child, not to provide Stavros and Lulu with an offspring, but to produce an heir for Helena with Luke's lineage.

Cassadine VictorValentinCharlotte Hero 2022 — Victor, Valentin, & Charlotte - 3 generations (2022)

In 2019, Nikolas was revealed to be alive, returning to reclaim his life and disclosing that Valentin is supposedly not a Cassadine. It was later unveiled that Valentin is not Mikkos' son but Helena's, thus negating his claim to the Cassadine fortune. Following Nikolas' exposure of Valentin and confirmation as the rightful heir, Valentin departed from Spoon Island, leaving Nikolas as the sole proprietor once again. Nikolas and Ava Jerome seized this moment to marry at Wyndemere. In 2021, Victor Cassadine was found to be alive and confessed to fathering Valentin with Helena, affirming his blood relation to the family.

Cassadine Victor-Nikolas 2022 — Victor admonishes Nikolas for his stupidity (2022)

In August 2022, Nikolas was revealed to have had a one-night stand with Esme Prince, the then-girlfriend of his son Spencer. When Nikolas' then-wife, Ava Jerome, discovers this, she confronts Esme, leading to a fight that results in Esme falling from the Wyndemere Parapet and being presumed dead. Esme later returns to Wyndemere to inform Nikolas of her pregnancy, claiming he is the father and offering to take a paternity test. Viewing the baby as leverage, she blackmails Nikolas, who then confines her to an abandoned suite in the castle. Esme manages to escape on New Year's Eve 2022 by intentionally falling from the parapet into the ocean. She survives, but with amnesia and is detained at Spring Ridge Prison. On February 15, 2023, the baby is born with assistance from his paternal grandmother, Laura Webber, and his maternal great uncle, Dr. Kevin Collins, along with paramedics. The baby is named Ace Niklosovich Prince-Cassadine.

Davis Girls[]

Alexis, now bearing the Davis surname, has three daughters. As a teenager, she had a one-night stand, resulting in her pregnancy and the birth of her first daughter, Samantha McCall. Samantha's father was later identified as Julian Jerome. Mikkos coerced Alexis into giving Samantha up for adoption immediately after her birth. In 2002, Alexis had another one-night stand with Sonny Corinthos, leading to the birth of their daughter, Kristina Adela Corinthos-Davis, named in memory of her deceased sister.

Sam arrived in Port Charles in 2003, yet she and Alexis remained oblivious to their mother-daughter relationship. Sam's affair with Sonny led to her pregnancy, and she named the baby Lila McCall. When Kristina was diagnosed with leukemia, Alexis learned that Lila's stem cells could save her. Tragically, after Alexis sought Sam's consent for the treatment, Sam prematurely gave birth, and Lila was stillborn. Lila's stem cells saved Kristina, leaving Alexis thankful and Sam heartbroken. In 2005, Alexis wed Sonny's half-brother Ric Lansing and welcomed her third daughter, Molly Lansing-Davis.

It was not until 2006 that Alexis and Sam discovered their familial bond; both initially rejected the relationship. The tension escalated when Alexis caught Ric and Sam together, leading to her divorce from Ric.

Cassadine AlexisValentin RaisedbyWolves 2020 — Alexis & Valentin, "Raised by Wolves" (2020)

Cassadine Detente 2023 — Valentin & Spencer come to a detente (2023)

Today, Alexis and Sam have forged a strong bond, with Sam being very protective of her younger sisters, Kristina and Molly. In 2012, Sam welcomed her son with her ex-husband Jason Morgan, whom they named Daniel Edward Morgan. In 2017, Sam had her second child, a daughter named Emily Scout Cain, with former Navy SEAL and Jason's identical twin, Drew Cain.

Cassadine Chess set 2021 — Cassadine chess set

Helena's Will[]

On March 14, 2016, Helena's will was read at Wyndemere Castle with Laura, Nikolas, Lulu, Alexis, Sam, Elizabeth Webber, and Hayden Barnes present, with Scott Baldwin as executor of the will. Helena bequeathed the following via video recording:

To Sam, she left one cent, to be split equally with her sisters, because "that's all any child of Alexis is worth."
To Alexis, she left a music box, playing the last song her mother ever sang and inside was the knife Helena used to slit her mother's throat.
To Elizabeth, she left a handwritten document called "Jake's Adventure," detailing his life when he was held captive by Helena.
To Nikolas, she left a portrait of herself (later revealed to hold a codicil to Mikkos' will) and informed him that she left everything else to the Cassadine Foundation, because she felt that he betrayed her.
To Lulu, she left an empty envelope and warned her to remember what she said and not to ignore her gift or she may regret it.
To Laura, she left a box with a single key and says "You took from me the thing I loved most, my beloved Mikkos. But because I am the better person, I'm giving you the key to what you have loved and lost."

Charlotte Anything for Cassadine Family 2023 — Under Victor's influence (2023)

Victor's Will[]

On May 30, 2023, Victor's will was read at the Collins Penthouse with Laura, Spencer, Alexis, and Ava in attendance. Sam, Anna and Valentin were invited but did not attend, while Martin Grey stood proxy for Valentin. He bequeathed the following via video recording:

To Ava, he left a rendering of her "first true love" - a picture of a gargoyle.
To Alexis, he left a Matryoshka doll, dating back to the Romanovs. Inside the doll were smaller versions of itself representing each of her daughters.
To Sam, he left a deck of rare tarot cards, so that she might one day use them to be "lucky in love." (These could be the cards used to condition Drew Cain.)
To Charlotte, he left a necklace and pendant engraved with the Cassadine family crest, to remind her of who she is and who she will "one day become."
To Valentin, whom he called the "rotten apple of my eye," he left "a rare piece of antiquity," the severed middle finger from a statue of the sun god Apollo.
To Spencer, he returned the box of two turtle dove figurines and spoke of safeguarding his family; a key was hidden underneath.
To Nikolas, the deed to a "home away from home" located in Chechnya. Entrusted to Spencer while his father is MIA.
To Anna, the truth exposed from her secrets - it is unknown what truth and based on what secrets, but it led to her very public arrest by the WSB.
To Laura, his worthy adversary, the knowledge that she beat him and can live in peace.

Cassadine Industries[]

CI Alexis Spencer Estate PPW 2023 — Cassadine Industries codicil (2023)

Cassadine Industries is a major international conglomerate, established by the Cassadine family in the late 1970s initially as a facade for illicit activities. However, the enterprise flourished under the leadership of Mikkos, Stavros, Helena, Valentin, and Nikolas, among others. In December 2005, an individual Cassadine Industries account was valued at approximately $15 million. By May 2009, the conglomerate's worth had soared to over $20 billion.

In November 2016, Valentin Cassadine assumed the role of CEO at Cassadine Industries after a hidden will from Mikkos disclosed that he bequeathed the entire Cassadine Estate to his eldest living son. With the deaths of Stavros and Stefan, Valentin was presumed to be the sole surviving son, thus nullifying any inheritance claims from Nikolas and Spencer, and establishing himself as the primary heir to the Cassadine Empire, with his daughter Charlotte set to succeed him. However, in August 2019, a codicil to Mikkos' will surfaced, proving Valentin to be Helena's son, not Mikkos', which led Nikolas to declare that he and Spencer were the rightful heirs.

On September 15, 2023, at The Invader, Alexis and Spencer reviewed the legal codicil for CI. With the Cassadine estate poised to transfer to him six months after Nikolas' departure, Spencer found himself puzzled by the legal jargon in the document he received. Alexis agreed to examine the document, acknowledging its complexity and the need for time to decipher it. Spencer expressed his gratitude for her assistance and the support of family in this matter.

Descendants[]

Princess Anya Cassadine
A Cassadine princess described as having hair "the color of fire." She was known throughout Russia for her joie de vivre. Her hairpin was given to Kristina Cassadine by Stefan Cassadine before he departed for Milan in 2002.

Prince Nikolai Cassadine

Nikolas Cassadine (I)
A Cassadine ancestor that lived in the 1800s. Prior to going to war he had a bracelet made for his wife that symbolized the love that he pledged to her forever. He was killed in the war, but his wife never remarried and for 60 years she wore his bracelet. The bracelet was smuggled out of St. Petersburg in the 1900s in the lining of a bodice belonging to a Cassadine woman. Legend holds that when a Cassadine gives a woman that bracelet, he gives her his heart. Nikolas Cassadine gave the bracelet to Emily Quartermaine in 2003.

Prince Stanislaus Cassadine
Stanislaus Cassadine never appeared onscreen. He was mentioned by Helena Cassadine in a conversation with her great-grandson, Spencer. Helena described him as a "blood-thirsty, cut-throat rebel," that was the most powerful Cassadine of them all. He was said to have tripled the Cassadine family power base before he met an untimely death. He was married to Katya Cassadine, with whom he had one son, Ivan and a daughter, Irina.^[1] Stanislaus was also the grandfather of Mikkos, Victor, Tony and Sophia Cassadine. When Nikolas Cassadine proposed to Emily Quartermaine in 2003, he gifted her with Katya's engagement ring, because she was known to be "somewhat normal" among the other crazy Cassadines.^[2]

Prince Ivan Cassadine
Ivan Cassadine never appeared onscreen. He is the only known son of Stanislaus and Katya Cassadine. Ivan is notable as being the father of Mikkos, Victor, Tony and Sophia Cassadine—the four children he had with his wife. Based on Mikkos' middle name which is "Ivanovich" -- all of the children in the Cassadine family have a form of their father's name in their middle name.

Princess Irina Cassadine (I)
Irina Cassadine never appeared onscreen. She is the only known daughter of Stanislaus and Katya Cassadine. She was mentioned as being Stefan Cassadine's great aunt and as having worn the traditional Cassadine engagement dress three times and whose first two husbands "disappeared without explanation."

Prince Mikkos Ivanovich Cassadine
(c1920 - September 18, 1981)

Main article: Mikkos Cassadine

Mikkos is the son of Ivan Cassadine. He arrived in Port Charles in 1981 as the mastermind behind a plot to attain world domination by holding the world to ransom through the use of a weather machine that could create severe snowstorms. Mikkos' plans were soon foiled by Luke and Laura and after a struggle with Luke, Mikkos dies after falling into his own ice chamber. Mikkos had four children; two sons, Stavros and Stefan with his wife Helena Romanov Cassadine, two daughters, Alexis and Kristina with his mistress Kristin Bergman.

Anthony Cassadine
(c1944 - September 18, 1981)

Main article: Tony Cassadine

Tony is the son of Ivan Cassadine. He arrived in town as a wealthy businessman using the alias Tony Castle, and donated money to General Hospital in an attempt to make inroads with the people of town. Tony coveted the Ice Princess diamond, which was the source of power for his brother Mikkos' weather machine. He had a romantic relationship with Alexandria Quartermaine and the two worked together to recover the stolen diamond. Tony and Alexandria are frozen to death after they unknowingly walk into Mikkos' ice chamber.

Victor Cassadine
(c1940s/50s - May 5, 2023)

Main article: Victor Cassadine

Victor is the third son of Ivan Cassadine. He came to town in 1981 along with brothers Mikkos and Tony, and was a part of their plan to steal the Ice Princess diamond and use it to power a weather machine that would allow them to control the world. Victor had a brief romantic relationship with actress, Tiffany Hill. After their plot was foiled by Luke Spencer, Victor was sent to prison and wasn't heard from in years. Victor returned in 2014 as the head of the WSB. Dr. Liesl Obrecht later shot and left him for dead in order to keep Det. Nathan West's paternity a secret. He was discovered alive and working with Peter August in 2021, at which time he was revealed to be Valentin's biological father and Charlotte's biological grandfather. He is killed from a drone strike by the WSB when he attemps to release a pathogen that will kill 80% of the population.

Sophia Cassadine-Davidovitch
Sophia is the only daughter of Ivan Cassadine. She was never portrayed onscreen, but was mentioned as the sister of Mikkos, Tony and Victor. Mikkos' illegitimate daughter, Alexis Davis is raised with Sophia's married surname as Alexis Davidovitch.

Petros Cassadine
(died after 1985)

Main article: Petros Cassadine

Petros came to town in 1985 as the cousin of Mikkos, Tony, Sophia, and Victor. He looked identical to Mikkos. While in town he visited General Hospital to monitor how the Cassadine money was being spent. He also interacted with Robert Scorpio and Sean Donely while trying to acquire a spy ship called, The Venture. Petros was enraged when Sean and Robert, both spies with the World Security Bureau, blocked his purchase of the ship and left town vowing vengeance on them both.

Dimitri Cassadine
(born c1970s)

Main article: Dimitri Cassadine

Dimitri arrived in Port Charles in 1986 as the cousin of Mikkos Cassadine. He came to town as a poor Cassadine cousin from Brazil and established a business relationship with Sean Donely and the Quartermaine family. He worked together with Sean to bring down the Quartermaines and steal their family fortune. He betrayed Sean, who in turn tried to warn the Quartermaines of Dimitri's plans, but it was too late. Dimitri successfully acquired the entire Quartermaine fortune and fled to Brazil. He was never heard from again.

Prince Stavros Cassadine
(1957 - September 16, 2014)

Main article: Stavros Cassadine

Stavros, the eldest son of Mikkos and Helena, arrives in town in 1983, fixated on Laura Spencer. He abducts Laura, claiming her husband Luke is deceased. During her confinement, Laura bears their son, Nikolas. Once Helena discloses Luke's survival, Laura immediately leaves Stavros. Stavros pursues Laura to Port Charles, seeking to reclaim her, but after a confrontation with Luke, he seemingly perishes, tumbling down a flight of stairs at GH. In 2001, Helena resurrects Stavros, who had been preserved in GH's basement for over ten years. He is thought to be dead once more when Luke casts him into a bottomless pit. In 2013, Stavros, found to be alive, seizes Laura's daughter, Lulu. Lulu is saved, and Laura apparently ends Stavros's life by confining him in a cryo-chamber. In 2014, Victor Cassadine informs Robin Scorpio-Drake that Stavros and Helena are both alive, cryogenically frozen. Later, Stavros is fatally shot by Lulu's then-husband, Dante Falconeri.

Prince Stefan Cassadine
(August 13, 1960 - October 10, 2003)

Main article: Stefan Cassadine

Stefan is the second and youngest son of Mikkos and Helena. During his youth, Helena always had a preference for Stavros. Stefan cared for his illegitimate half-sister Alexis, who was an outcast in the household and later raised his brother Stavros' son Nikolas as his own. He arrived in Port Charles in 1996 and became the CEO of General Hospital. Stefan is killed in 2003 after he is stabbed by Luke Spencer and falls off a cliff on Spoon Island.

Alexis Davis
(born January 29, 1964)

Main article: Alexis Davis

Alexis, born Princess Natasha Alexandra Mikkosovna Cassadine, is the oldest daughter of Mikkos and his mistress, Kristin Bergman. As a child, Alexis witnesses Helena kill her mother. She is raised in Mikkos' house as a poor relative and is tormented by Stavros, while Stefan serves as her protector. She arrived in town in 1996 with Stefan who brings her to aid in the legal side of his vendetta against Luke Spencer. Luke helps Alexis discover her true identity as Mikkos' daughter. She received her royal title in 2000, which she later renounced. Alexis has three daughters; Sam McCall, with Julian Jerome, Kristina Corinthos-Davis, with Sonny Corinthos and Molly Lansing-Davis, with Ric Lansing.

Princess Kristina Cassadine
(c1975 - August 6, 2002)

Main article: Kristina Cassadine

Kristina is the second and youngest daughter of Mikkos and his mistress, Kristin Bergman. Her mother is murdered by Helena when she is only a baby and her father sends her away to a foster family to protect her. In 2001, she comes to town after hiring a private investigator and reunites with Alexis as an adult. Kristina is killed a year later in 2002 after being caught in a warehouse explosion meant for mobster Sonny Corinthos. Alexis names her second-born daughter after her sister.

Valentin Mikkosovich Cassadine
(born c1960)

Main article: Valentin Cassadine

Valentin was first mentioned in 2009 as the previously unknown illegitimate son of Mikkos and an unnamed woman. Helena described Valentin as "more treacherous than any other Cassadine" and "the Cassadine that all other Cassadines fear." She herself was terrified of him. Disowned by Mikkos years earlier, Valentin had been out of the picture until Helena tried to control him. He poisoned Helena, seeking revenge on her, Luke, the Cassadines, and the Spencers. Valentin has a daughter, Charlotte, with Lulu Spencer, born via surrogate in May 2009. By November 2016, he owned Cassadine Industries. On January 6, 2020, it was disclosed that Valentin is Helena's son, not Mikkos'. In October 2021, while in Greece, Valentin was captured by a living Victor Cassadine, who then revealed himself as Valentin's father.

Prince Nikolas Mikail Stavrosovich Cassadine
(born November 5, 1977)

Main article: Nikolas Cassadine

Nikolas is the only son of Stavros Cassadine and Laura Collins, born in 1983. He is raised by his uncle Stefan after his mother leaves and his father is presumed dead. Laura tried to secretly reclaim Nikolas in 1984, but when Helena presumably murdered her mother, Lesley Webber, Laura kept the secret of his existence to protect her loved ones. Nikolas comes to Port Charles in 1996 to save the life of his half-sister, Lulu who needs a bone marrow transplant. In 2006, he became a single father when his fiancée dies after giving birth to his son whom he named Spencer. In 2016, Nikolas was presumed dead after getting shot by Valentin during a struggle and falling off a balcony. Nikolas was also the former owner of the family business, Cassadine Industries. In 2019, Nikolas was revealed to be alive and he returned to Port Charles, staying hidden until the codicil to Mikkos' will was found. He revealed himself to everyone and revealed that the entire estate belongs to him, not Valentin and also that Valentin is Helena's son, not Mikkos'. He ended up losing Wyndemere after cheating with the manipulate 20-year-old Esme Prince, which resulted in her pregnancy, then giving it to his ex-wife Ava Jerome in the divorce.

Samantha McCall
(born May 11, 1980)

Main article: Sam McCall

Sam is Alexis' daughter with mob boss, Julian Jerome, born when Alexis was only sixteen years old. Sam was given up for adoption and raised by a con artist adoptive father, Cody McCall. Sam came to town with Cody in 2003 to find the five lucky cards of the "Dead Man's Hand." In 2006, she discovered that Alexis is her biological mother. The two had a strained relationship that mended overtime. Sam has given birth to three children. In 2004, she had a stillborn daughter, Lila McCall, with Sonny Corinthos. In 2012, she welcomed her son, Danny Morgan, with Jason Morgan. In 2017, she and Drew Cain welcomed a daughter named Scout Cain.

Kristina Adela Corinthos-Davis
(born November 19, 1993)

Main article: Kristina Corinthos-Davis

Kristina is Alexis' daughter with mob boss, Sonny Corinthos, born in 2002. As a baby, she is believed to be the child of Ned Ashton. The truth of her paternity is revealed after she is diagnosed with aplastic anemia and is in need of stem cells to save her life. Kristina was raised predominantly by her mother and had little contact with her father. In 2009, the character is rapidly aged to a teenager and had tumultuous relationships with both her parents. She leaves town in 2013 to attend Wesleyan University and returned in 2015. She left again in 2017, but has returned on a recurring basis since 2018.

Molly Lansing-Davis
(born November 10, 1997)

Main article: Molly Lansing-Davis

Alexis' daughter with Ric Lansing, Molly is born in 2005. The character was rapidly aged in 2009, she was primarily raised by her mother. Molly is characterized as precocious and smart and has shown much interest in the Cassadine side of her heritage. After a bus accident Molly suffered from post-traumatic stress disorder. She recently graduated from high school and has written a book, Maine Squeeze, and co-authored its' prequel, Love in Maine, with Connie Falconeri. Molly has been in a relationship with T.J. Ashford since she was a young teen, and as of 2020 they are in a domestic partnership.

Charlotte Honor Cassadine
(born May 5, 2008)

Main article: Charlotte Cassadine

Valentin's daughter with Lulu Spencer via IVF and was carried by Claudette Beaulieu. Charlotte was born in 2006 at New York Methodist Hospital in Manhattan. Due to Claudette's lies she was formerly believed to be the daughter of Det. Nathan West and then of Dr. Griffin Munro. Following the end of Claudette's relationship with Valentin, she alleged that he began threatening them. Fearing for their safety, Claudette attempted to distance Charlotte from him. On December 9, Valentin disclosed that Claudette served only as a surrogate, and that Lulu is Charlotte's biological mother. Come October 2017, it was disclosed that Valentin and Lulu had been granted shared custody. By October 2021, it emerged that Charlotte's biological grandfather is Victor Cassadine.

Prince Spencer Stefan Niklosovich Cassadine
(born February 20, 2001)

Main article: Spencer Cassadine

Prince Spencer Cassadine is the first son of Nikolas and his only child with Courtney Matthews, born in 2006. He was originally thought to be the son of Jasper Jacks, due to Jax switching the paternity test. Courtney dies shortly after giving birth to Spencer and when Robin Scorpio reveals the truth of his paternity, Nikolas is given custody. Nikolas struggled with being a good father to Spencer. When Spencer and Nikolas temporarily leave town in 2011, Nikolas is shown to have a better grip on fatherhood when they return two years later. After Nikolas' presumed death in 2016, Spencer leaves Port Charles for boarding school. He returned in 2022, newly graduated, with a manipulative girlfriend, Esme Prince. He scorned his father, and hated his then-stepmother, Ava Jerome, which led to his girlfriend manipulating him into stalking her. While trying to rebuild a relationship with his father, he fell in love with Trina Robinson, and his jealous ex framed her for a heinous crime.

Lila McCall
(stillborn November 8, 2004)

Main article: Lila McCall

Sam's daughter with mob boss, Sonny Corinthos, who was stillborn in 2004. Jason Morgan helps Sam through her pregnancy and acts as the child's father in order to keep the marriage of Sonny and his wife Carly Corinthos together. Sam intends to name the baby after Jason's late grandmother, Lila Quartermaine, but the baby's legal name at the time of her death is "Baby Girl McCall."

Daniel Edward Morgan
(born June 1, 2012)

Main article: Danny Morgan

Danny is the son of Sam and Jason Morgan, born in 2012, though he was originally believed to be the son of Jason's alleged twin brother, Franco due to Heather Webber switching the paternity test. Danny was switched shortly after birth with Victor Lord III, the deceased newborn of Téa Delgado, and lived in Llanview, Pennsylvania with Téa. The baby switch was revealed four months later and Danny was returned to Jason and Sam and is named after Sam's late brother, Danny McCall and Jason's late grandfather, Edward Quartermaine. Unfortunately, Jason was presumed dead shortly before a paternity test proves he is Danny's biological father. Danny was diagnosed with leukemia in 2013 and recovers after he receives a bone marrow transplant from his grandfather, Julian Jerome. In 2014, Jason returned with amnesia and a changed appearance, and by 2015, he was raising Danny with Sam, having discovered his identity. However, in 2017, it was revealed that the man believed to be Jason for years was actually his twin brother, Andrew Cain, while the individual known as "Patient 6" was confirmed to be the real Jason. Jason and Sam continued to co-parent Danny and ultimately reconciled between late 2018 and early 2019.

Emily Scout Cain
(born February 28, 2017)

Main article: Scout Cain

Emily is the daughter of Sam and Drew Cain, born in 2017. She was born during a snow storm after her mother was kidnapped by Olivia Jerome. She was delivered by her father and named after her late aunt, Emily Quartermaine. She received the middle name "Scout" at her older brother Danny's request and is mainly known by that name.

Prince Ace Niklosovich Prince-Cassadine
(born February 15, 2023)

Main article: Ace Prince-Cassadine

Prince Ace Prince-Cassadine is the second son of Nikolas Cassadine from a one-night-stand he had with his son's then girlfriend, Esme Prince. Once his wife Ava learned of their affair, she fought with Esme, who went over the castle parapet, and was presumed dead. Two months later, she turns up alive, having broken into the castle, and is caught by Nikolas. He's stunned to learn of her condition, that she promises is a real pregnancy, and that he's the father - she's willing to take a paternity test. She sees the baby as her get-out-of-jail-free card, blackmailing him. He agrees, but ends up locking her into an abandoned suite in the castle. Esme was held at Wyndemere secretly as a hostage until she gives birth, with Elizabeth Baldwin in on the plan, and taking care of her prenatal needs as her private nurse. On New Years Eve, Esme plans to set fire to the storage room using a match in order to escape Nikolas, then she intentionally falls off the parapet into the ocean. She survives, but has amnesia, and is taken into custody at Spring Ridge Prison. On February 15, 2023, the baby was born in Wyndermere Castle, with the help of his paternal grandmother Mayor Laura Collins and maternal great uncle Dr. Kevin Collins, and paramedics, while Nikolas is on the run. Almost a year later, upon realizing that Esme has regained her memory and poses a threat, Nikolas departs with Ace to safeguard him. Subsequently, he comes back and entrusts Ace to Laura and Kevin, who then adopt him.