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- Serial Killers
- Seth Baker (Michael Rodrick)
- Seymour Katz (Jordan Charney)
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- Sharon Grant (Brea Bee)
- Sharon Pinkham (Sharon DeBord)
- Sharon Wyatt
- Shaun Benson
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- Shawn Butler (Sean Blakemore)
- Shawn Butler and Alexis Davis
- Shawn Butler and Carly Spencer
- Shawn Butler and Jordan Ashford
- Shawn Phillips (Owen Saxon)
- Shawn Shaw (Chad Doreck)
- Shawn or Sean (disambiguation)
- Sheila Cantillion (Stacey Cortez)
- Shell Danielson
- Shell Kepler
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- Shep Casey (Bradley Lockerman)
- Sherilyn Wolter
- Sherri Anderson (Jerin Forgie)
- Shiloh (disambiguation)
- Shirley (disambiguation)
- Shirley Smith (Michael Learned)
- Shriners Hospital for Children
- Sibley Gamble (Veronica Cartwright)
- Sibling Rivalries
- Sienna Colby (Cynthia Zitter)
- Silas Clay (Michael Easton)
- Silas Clay and Ava Jerome
- Silas Clay and Nina Reeves
- Silva (Joe Nieves)
- Silver Water Aftercare
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- Simon (disambiguation)
- Simon Scott
- Simone Hardy (Felecia Bell)
- Siobhan Spencer (Erin Chambers)
- Skeeter McKee (Jaime McEnnan)
- Skye Chandler-Quartermaine (Robin Christopher)
- Slick Jones (Eddie Ryder)
- Sly (disambiguation)
- Sly Eckert (Glenn Walker Harris, Jr.)
- Sly Thomas (Gavin Houston)
- Smith mob family
- Soap Tropes
- Soap opera
- Society Setups
- Sofia (disambiguation)
- Sofia Mattsson
- Sonny's Coffee Shop
- Sonny (disambiguation)
- Sonny Corinthos (Maurice Benard)
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